RFI-641, a potent respiratory syncytial virus inhibitor.
نویسندگان
چکیده
Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV agent with potent in vitro and in vivo activity. RFI-641 is active against both RSV type A and B strains. The viral specificity and the large therapeutic window of RFI-641 (>100-fold) indicate that the antiviral activity of the compound is not due to adverse effects on normal cells. The potent in vitro activity of RFI-641 can be translated to efficacy in vivo: RFI-641 is efficacious when administered prophylactically by the intranasal route in mice, cotton rats, and African green monkeys. RFI-641 is also efficacious when administered therapeutically (24 h postinfection) in the monkey model. Mechanism of action studies indicate that RFI-641 blocks viral F protein-mediated fusion and cell syncytium formation.
منابع مشابه
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The Journal of Clinical Investigation http://www.jci.org Volume 124 Number 5 May 2014 1891 8. Razinkov V, Gazumyan A, Nikitenko A, Ellestad G, Krishnamurthy G. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001;8(7):645–659. 9. Garg R, Latimer L, Simko E, Gerdts V, Potter A, van den Hurk S. Induction of mucosal immunity and protection by ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 46 3 شماره
صفحات -
تاریخ انتشار 2002